6/20/2023 0 Comments Adult pluripotent stem cellsJournal of Cellular Biochemistry, 80(3), 455–460.Ĭortiella, J., Nichols, J. Identification and initial characterization of spore-like cells in adult mammals. P., Roy, A., Cortiella, J., Bonassar, L., & Vacanti, C. The bone marrow “mystery population” of stem cells 20 years later-a puzzle solved? Blood, 126, 2392. Molecular Reproduction and Development, 80(8), 677–690. Very small embryonic-like cells: biology and function of these potential endogenous pluripotent stem cells in adult tissues. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. I., Henegariu, O., Hwang, S., Gardner, R., et al. Characterization of a population of cells in the bone marrow that phenotypically mimics hematopoietic stem cells: resting stem cells or mystery population? Stem Cells, 16(1), 38–48. Phenotypic and functional characterization of the hematopoietic stem cell. A plethora of human pluripotent stem cells. Clarifying stem-cell therapy’s benefits and risks. Vision loss after intravitreal injection of autologous “stem cells” for AMD. The Indian Journal of Medical Research, 141(2), 154–161. Stem cells, progenitors & regenerative medicine: a retrospection. Blood Cells Molecules & Diseases, 51(1),3–8. (2013) Hematopoietic stem cells are pluripotent and not just “hematopoietic”. Plasticity: time for a reappraisal? Science, 296, 2126–2129. International Journal of Stem Cells, 9(1), 1–2. Questions surrounding iPS cells in Japan. Age-related accumulation of somatic mitochondrial DNA mutations in adult-derived human iPSCs. Kang, E., Wang, X., Tippner-Hedges, R., Ma, H., Folmes, C. Genomic instability of iPSCs: challenges towards their clinical applications. Yoshihara, M., Hayashizaki, Y., & Murakawa, Y. Molecular obstacles to clinical translation of iPSCs. They will likely prove to be a game changer in the field of stem cells biology, for regenerative medicine and for our understanding of cancer initiation. PSCs in adult tissues have remained elusive until now as they possibly get unknowingly discarded due to their small size and inability to pellet at 1000–1200 rpm (250 g). Such adult PSCs could be the ideal stem cell candidates to bring about endogenous regeneration compared to ES/iPS cells grown in Petri dish and also score better over ASCs which in fact are tissue committed progenitors with limited regenerative potential that differentiate from the PSCs. This article is a sincere attempt to review research carried out by various investigators over the last two decades and various attempts to demonstrate their presence in adult tissues. However, the very presence of PSCs in adult tissues is mired with controversies. These PSCs could also be the embryonic stem cells in adult tissues that were proposed to initiate cancers according to the Embryonic Rest Hypothesis put forth in the nineteenth century. They are thought to be more primitive than the adult stem cells (ASCs), serve as a backup pool to give rise to ASCs and thus play a crucial role in maintaining life-long homeostasis. Besides embryonic stem cells (ES) and induced pluripotent stem cells (iPS), it has been postulated that pluripotent stem cells (PSCs) may also exist in various adult tissues. Stem cells have fascinated scientists for a long time and huge research efforts have been put into them as they have the potential to regenerate diseased organs.
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